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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac danger components using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, likely secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the right coronary artery. Physicians and sufferers should be aware of the scientific consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which can contribute to abnormal vessel reactivity.
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In addition, the data obtainable in the literature does not account for the steroid kind or dose, as neither may be known. Patients also may be taking concomitant stimulants, corresponding to ephedra, which may confound knowledge and the potential for antagonistic occasions . It is likely that the frequency of cardiac events is underreported in the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which include more than 30 natural and synthetic derivatives of testosterone, might trigger a wide spectrum of medical sequalae.
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